People bemoan how simple it is to gain weight. Fat accumulation, on the other hand, is a sophisticated process that involves almost all of the body’s tissues and organs, according to scientists.
Fat tissue, which contains millions of fat cells, is what generates the love handles that individuals desire to get rid of so badly. The fat cells are loaded with triglycerides and eventually expand like balloons. Obese people may have “fatter fat cells” as a result of this.
The amount of fat cells in both thin and obese people is more or less fixed during childhood, according to research. As a result, an adult’s fat cell count remains relatively consistent. The weight of the body fluctuates due to changes in fat cell size.
The team of Zhao Yue, a researcher from Nanjing University in China, set out to figure out how fat accumulates in the body built a high-fat diet model for mice to simulate the state of overeating in humans.
They found that when too much fat flooded into the body, it didn’t immediately find its way to the fat tissue, but somewhere else.
“After the mouse eats a high-fat diet, the liver is the first to respond, which accumulated fat earlier than the fat tissue and skeletal muscles,” Zhao said.
Scientists have known for a long time that the liver can communicate with other organs from afar, sending out small molecules as messages to control the operations of distant organs. However, Zhao discovered that one form of molecule, known as an exosome, only enters fat cells. That suggests there is a channel of communication between the liver and the fat tissue.
And if you continue to consume a high-fat diet, the information carried by the exosome changes. “After a long time, fat cells can no longer bear the metabolic pressure. The liver changes its order. The number of (fat cells) has reached a peak. Their volume has to become bigger,” Zhao explained.
The body’s plan is clear: it will generate more fat cells as a last resort, but it will also make fat cells larger in the long run. There is, however, a limit.
Excess fat will be stored in the blood vessels and subsequently the liver after years of binge eating, damaging the metabolism.
The fat alters the contour of the body. The discovery of exosomes, on the other hand, excites scientists. Because those tiny messengers can recognize and target fat tissue, new medication choices for disorders like obesity and diabetes may be on the way.